The St. Louis Rams will have Steven Jackson in the backfield, which means Isaiah Pead is inactive for the game.
Matt Holliday will return to the Cardinals' lineup after injuring his elbow on a bean ball during Friday's win over the Washington Nationals.
Jake Westbrook's oblique injury will sideline the St. Louis Cardinals pitcher for an indefinite amount of time.
The St. Louis Rams have signed linebacker James Laurinaitis to a five-year, $41.5 million extension that runs through 2017 and includes $23.5 million guaranteed.
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