David Freese is nursing a sore ankle, and it is unclear when he'll return, although it could be on Friday following the Cardinals' off day. Meanwhile, Beltran is apparently just getting a standard rest day. Matt Carpenter is in at third base for the Cards, while Adron Chambers will take Beltran's spot in right field.
Here are the full lineups:
Chris Carpenter is back on the mound on Wednesday, after making his first start of the season last week. He allowed two runs in five innings in a loss to the Chicago Cubs. The Astros will counter with Bud Norris, who remains one of the better strikeout pitchers among NL starters, despite having a poor record and ERA.
First pitch is scheduled for 7:05 p.m. CT.