This is all starting to look familiar to St. Louis Rams fans—Mark Clayton will miss the remainder of the 2010 NFL season after injuring his knee in the first quarter of the Rams’ blowout loss to the Detroit Lions.

The Rams lost Donnie Avery to a similar injury in the preseason, which led to their acquisition of Clayton. Clayton was leading the Rams in receiving yards with 300 at the time of the injury. The Post-Dispatch has an earlier report from the AP, in which Coach Steve Spagnuolo is quoted as saying “It doesn’t look good… we’re not optimistic.”