The St. Louis Rams face the Arizona Cardinals for the first of two meetings to kick off their 2010 schedule. With Kurt Warner prepared to commence Dancing with the Stars and Matt Leinart on the outs, it would be a good time for the Rams to continue their hot preseason start.
The remainder of the schedule:
| DATE | OPPONENT | TIME |
| Sept. 12 | Arizona Cardinals | 3:15 |
| Sept. 19 | at Oakland Raiders | 3:05 |
| Sept. 26 | Washington Redskins | 3:05 |
| Oct. 3 | Seattle Seahawks | 12:00 |
| Oct. 10 | at Detroit Lions | 12:00 |
| Oct. 17 | San Diego Chargers | 12:00 |
| Oct. 24 | at Tampa Bay Buccaneers | 12:00 |
| Oct. 31 | Carolina Panthers | 12:00 |
| Nov. 7 | BYE WEEK | |
| Nov. 14 | at San Francisco 49ers | 3:15 |
| Nov. 21 | Atlanta Falcons | 3:05 |
| Nov. 28 | at Denver Broncos | 3:15 |
| Dec. 5 | at Arizona Cardinals | 3:15 |
| Dec. 12 | at New Orleans Saints | 3:05 |
| Dec. 19 | Kansas City Chiefs | 12:00 |
| Dec. 26 | San Francisco 49ers | 12:00 |
| Jan. 2 | at Seattle Seahawks | 3:15 |