First pitch is set for 3 p.m. CT at Busch Stadium, as the 34-year-old Lohse will hope to get the better of a San Francisco lineup that has already produced 11 runs so far in the series. Along with smacking 12 hits in Monday's win, Giants hitters have worked deep into counts and forced St. Louis to throw an inordinate amount of pitches after just two games.
Unable to catch a break against a stellar Giants rotation, the Cardinals will square off against San Francisco righty Matt Cain on Wednesday afternoon. Cain tossed a perfect game back in early June, but has yielded three earned runs in each of his two postseason starts. Along with outfielder Jon Jay's .667 career average against Cain in six appearances, St. Louis slugger Carlos Beltran holds a .389 career mark with five RBIs in 18 at-bats against the projected Game 3 starter.