Barring a somewhat unlikely World Series matchup, it will be the first time that Cardinals legend Albert Pujols plays against his old team after he left for the West Coast in free agency last winter.
He won't be the only familiar face in the AL West, as the Houston Astros, who faced off against St. Louis in some memorable playoff series over the last decade, will be switching leagues.
The move will give each league exactly 15 teams, which means that interleague play, once reserved for a few weeks in the summer, will now be occurring on an almost daily basis around MLB.
Each team will play 76 divisional games, 20 interleague games and 66 games against the other 10 teams in their respective leagues.
St. Louis will kick off the season on April 1 with a six-game road trip against the Arizona Diamondbacks and San Francisco Giants, while their home opener will be on April 8 against the Cincinnati Reds.