Jaime Garcia (4-7, 4.24 ERA) starts on the mound for the Cardinals after going six solid innings and allowing only three hits and two runs in a close 4-3 loss to the Los Angeles Dodgers on Sept. 15.
Houston will counter with right-hander Bud Norris (5-12, 4.93 ERA) on the hill. Norris missed his last scheduled start due to a blister on his right hand. He last pitched on Sept. 8, surrendering five runs on six hits in a 5-1 loss to the Cincinnati Reds.
The Cardinals currently sit a full two games ahead of the Dodgers in the National League Wild Card standings and 2½ games atop the surging Milwaukee Brewers.
St. Louis shut the Astros out on Wednesday night, 5-0, behind a strong outing from Lance Lynn, who won his sixteenth game of the season.
First pitch is set for 12:45 p.m. CT and will be televised on Fox Sports Midwest.
For more on the Astros, be sure to visit The Crawfish Boxes. Additional coverage on the Cardinals can be found at Viva El Birdos, while Baseball Nation is the place to go for news and analysis from around the league.