Starting pitcher Kyle Lohse allowed a grand slam to Michael Morse in the top of the first inning, on a play that was reviewed and overturned to a home run. Lohse would last six innings, striking out nine and walking just one, but those four runs would be enough, as the Cardinals late comeback fell short in the one-run loss.
The Cardinals managed three runs on starting pitcher Jordan Zimmerman in the bottom of the 7th, with John Jay tying the game in the bottom of the ninth inning on a sacrifice fly that scored Pete Kozma.
The Nationals would take a 6-4 lead in the top of the 10th, thanks to a Kurt Suziki two-run double.
Matt Holliday, back in the lineup in the No. 3 spot, went 0-for-3 with a strikeout and a walk. Matt Carpenter would leave three on base, going 0-for-4 in the game. Shortstop Pete Kozma was 2-for-3 with two RBIs that came on a double in the seventh.
The rubber match between the Cardinals and Nationals is set to start at 1:15 p.m. CT on Sunday, with Lance Lynn taking the mound against Ross Detwiler.